منابع مشابه
Lipid-helix interactions in membrane receptors.
The integration of the transmembrane (TM) proteins in the lipid bilayer depend on lipid-protein interactions. The few crystal structures known for multiple membrane spanning proteins suggest a basic form composed of bundles of a-helices that pack together. In the membrane helix-helix and helix-lipid interaction define the helix arrangement in the folded receptor. Thus, the lipid-protein interac...
متن کاملModulation of glycophorin A transmembrane helix interactions by lipid bilayers: molecular dynamics calculations.
Starting from the glycophorin A dimer structure determined by NMR, we performed simulations of both dimer and monomer forms in explicit lipid bilayers with constant normal pressure, lateral area, and temperature using the CHARMM potential. Analysis of the trajectories in four different lipids reveals how lipid chain length and saturation modulate the structural and energetic properties of trans...
متن کاملIon-mediated nucleic acid helix-helix interactions.
Salt ions are essential for the folding of nucleic acids. We use the tightly bound ion (TBI) model, which can account for the correlations and fluctuations for the ions bound to the nucleic acids, to investigate the electrostatic free-energy landscape for two parallel nucleic acid helices in the solution of added salt. The theory is based on realistic atomic structures of the helices. In monova...
متن کاملBalancing Force Field Protein–Lipid Interactions To Capture Transmembrane Helix–Helix Association
Atomistic simulations have recently been shown to be sufficiently accurate to reversibly fold globular proteins and have provided insights into folding mechanisms. Gaining similar understanding from simulations of membrane protein folding and association would be of great medical interest. All-atom simulations of the folding and assembly of transmembrane protein domains are much more challengin...
متن کاملPredicting helix–helix interactions from residue contacts in membrane proteins
MOTIVATION Helix-helix interactions play a critical role in the structure assembly, stability and function of membrane proteins. On the molecular level, the interactions are mediated by one or more residue contacts. Although previous studies focused on helix-packing patterns and sequence motifs, few of them developed methods specifically for contact prediction. RESULTS We present a new hierar...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1996
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(96)79498-5